Publikationen seit 1995


  • Kalimuthu, P., Kruse, T. and Bernhardt, P. V. (2021)
    Deconstructing the electron transfer chain in a complex molybdoenzyme: Assimilatory nitrate reductase from Neurospora crassa.
    Biochim Biophys Acta Bioenerg. 1862, 148358.

  • Kalimuthu, P., Kruse, T. and Bernhardt, P. V. (2021)
    A Highly Sensitive and Stable Electrochemical Nitrate Biosensor.
    Electrochimica Acta. 386, 138480.

  • Probst, C., Yang, J., Krausze, J., Hercher, T. W., Richers, C. P., Spatzal, T., Khadanand, KCGiles, L. J., Rees, D. C., Mendel, R. R., Kirk, M. L., Kruse, T. (2021)
    Mechanism of molybdate insertion into pterin-based molybdenum cofactors.
    Nature Chemistry.

  • Simon J. Mayr, Ralf R. Mendel, Günter Schwarz
    Molybdenum cofactor biology, evolution and deficiency
    Biochim Biophys Acta, Mol Cell Res. (2021) 1868(1):118883. doi: 10.1016/j.bbamcr.2020.118883. Epub 2020 Oct 2.

  • Thomas W. Hercher, Jörn Krausze, Jing Yang, Martin L. Kirk and Tobias Kruse (2020)
    Identification and characterization of the Volvox carteri Moco carrier protein.
    Bioscience Reports. 40 (11)

  • Kurt Warnhoff, Thomas W. Hercher, Ralf R. Mendel, Gary Ruvkun
    Protein-bound molybdenum cofactor is bioavailable and rescues molybdenum cofactor-deficient C. elegans
    Genes & Development (2021) in press



  • Kruse, T. (2020).
    Eukaryotic Molybdenum Insertases.
    Encyclopedia of Inorganic and Bioinorganic Chemistry, R.A. Scott (Ed.).

  • Joern Krausze, Thomas W. Hercher, Archna Archna and Tobias Kruse.
    The structure of the Moco carrier protein from Rippkaea orientalis.
    Acta Cryst. (2020). F76.

  • Ralf R. Mendel, Thomas W. Hercher, Arkadiusz Zupok, Muhammad A. Hasnat and Silke Leimkühler.
    The Requirement of Inorganic Fe-S Clusters for the Biosynthesis of the Organometallic Molybdenum Cofactor.
    Inorganics 2020, 8, 43; doi:10.3390/inorganics8070043

  • Simon Wajmann, Thomas W. Hercher, Sabine Buchmeier, Robert Hänsch, Ralf R. Mendel and Tobias Kruse
    The First Step of Neurospora crassa Molybdenum Cofactor Biosynthesis: Regulatory Aspects under N-Derepressing and Nitrate-Inducing Conditions
    Microorganisms 2020, 8, 534; doi:10.3390/microorganisms8040534

  • Thomas W. Hercher, Joern Krausze, Sven Hoffmeister, Dagmar Zwerschke, Thomas Lindel, Wulf Blankenfeldt, Ralf R. Mendel and Tobias Kruse
    Insights into the Cnx1E catalyzed MPT-AMP hydrolysis.
    Biosci Rep. 2020 Jan 31;40(1):BSR20191806. doi: 10.1042/BSR20191806.



  • Plate, J., Sassen, W.A., Hassan, A.H., Lehne, F., Koester, R.W. and T. Kruse (2019).
    S-Sulfocysteine induces epilepsy-like behaviors in zebrafish.
    Front. Pharmacol. 10, 122.

  • Mendel, RR, and Hercher, TW
    Harvesting Moco.
    Nature Chem Biol. 2019 Mar 25. doi: 10.1038/s41589-019-0257-y.

  • Baillie, C. K., Meinen, R., Kaufholdt, D., Hänsch, S., Schmidt, N., Zwerschke, D., Rennenberg, H., Hu, B., Mendel, R.R., Hänsch, R.
    Apoplastic peroxidases enable an additional sulphite detoxification strategy and act as first line of defence upon exposure to sulphur containing gas.
    Environmental and Experimental Botany 157, 140-150.



  • Naumann, M., Hubberten, M. H., Watanabe, M., Hänsch, R., & Hoefgen, R. (2018).
    Sulfite reductase co-suppression in tobacco reveals detoxification mechanisms and downstream responses comparable to sulfate starvation.
    Frontiers in Plant Science 9, 1423.

  • Joern Krausze, Thomas W. Hercher, Dagmar Zwerschke, Martin L. Kirk, Wulf Blankenfeldt, Ralf R. Mendel and Tobias Kruse (2018).
    The functional principle of eukaryotic molybdenum insertases.
    Biochemical Journal, 475 1739-1753

  • Yahyazadeh, M., Meinen; R. Hänsch, R., Selmar, D. (2018).
    Impact of drought and salt stress on the biosynthesis of alkaloids in Chelidonium majus.
    Phytochemistry 152, pp. 204-212

  • Baillie, C. K., Kaufholdt, D., Meinen, R., Hu, B., Rennenberg, H., Hänsch, R., & Bloem, E. (2018).
    Surviving volcanic environments - Interaction of soil mineral content and plant element composition.
    Frontiers in Environmental Science, 6, 52.

  • de Cassas, D., Sydow, S., Schmidt, N., Behrens, P., Roger, Y, Hoffmann, A., Hoheisel, A. L., Glasmacher, B., Hänsch, R., Menzel, H. (2018).
    Attachment of nanoparticulate drug-release systems on poly(e-caprolactone) nanofibers via a graftpolymer as interlayer.
    Colloids and Surfaces B: Biointerfaces 163, pp. 309-320

  • Tocci, N., Gaid, M., Kaftan, F., Belkheir, A., Belhadj, I., Liu, B., Svatoš, A., Hänsch, R., Pasqua, G., Beerhues, L. (2018).
    Exodermis and endodermis are the sites of xanthone biosynthesis in Hypericum perforatum roots.
    New Phytologist 217: 1099-1112

  • Ordonez-Herrera N, Trimborn L, Menje M, Henschel M, Robers L, Kaufholdt D, Hänsch R, Adrian J, Ponnu J, Hoecker U (2018).
    The transcription factor COL12 is a substrate of the COP1/SPA E3 ligase and regulates flowering time and plant architecture.
    Plant physiology, 176, 1327-1340.

  • Dier, M., Meinen, R., Erbs, M., Kollhorst, L., Baillie, C. K., Kaufholdt, D., Hänsch, R. & Manderscheid, R. (2018).
    Effects of free air carbon dioxide enrichment (FACE) on nitrogen assimilation and growth of winter wheat under nitrate and ammonium fertilization.
    Global Change Biology. 24, e40-e54



  • Kaufholdt D, Baillie CK, Meinen R, Mendel RR, Hänsch R (2017).
    The Molybdenum Cofactor Biosynthesis Network: In vivo Protein-Protein Interactions of an Actin Associated Multi-Protein Complex.
    Frontiers in plant science, 8, 1946.

  • Klewe A, Kruse T, Lindel T (2017).
    Aminopyrazine Pathway to the Moco Metabolite Dephospho Form A.
    Chemistry. 23, 11230-11233.

  • Malcheska F, Ahmad A, Batool S, Müller HM, Ludwig-Müller J, Kreuzwieser J, Randewig D, Hänsch R, Mendel RR, Hell R, Wirtz M, Geiger D, Ache P, Hedrich R, Herschbach C, Rennenberg H (2017).
    Drought-enhanced xylem sap sulfate closes stomata by affecting ALMT12 and guard cell ABA synthesis.
    Plant Physiology, 174(2), 798-814.

  • Tocci N, Gaid M, Kaftan F, Belkheir AK, Belhadj I, Liu B,Hänsch R, Beerhues L (2017).
    Exodermis and endodermis are the sites of xanthone biosynthesis in Hypericum perforatum roots.
    New Phytologist. 217, 1099-1112.

  • Krausze J, Probst C, Curth U, Reichelt J, Saha S, Schafflick D, Heinz DW, Mendel RR, Kruse T (2017).
    Synthesis of the Molybdenum Cofactor: Dimerization of the plant enzyme Cnx1E is required for substrate binding.
    Biochemical Journal, 474, 163-178.

  • Leimkühler, S., and R.R. Mendel
    Molybdenum cofactor biosynthesis
    Molybdenum and Tungsten Enzymes, RSC Metallobiology Series No. 5 (Ed. R. Hille, C. Schulzke and M.L. Kirk), Royal Soc. Chem., Cambridge (UK).



  • Kaufholdt D, Baillie CK, Meyer MH, Schwich OD, Timmerer UL, Tobias L, van Thiel D, Mendel RR, Hänsch R (2016)
    Identification of a protein-protein interaction network downstream of molybdenum cofactor biosynthesis in Arabidopsis thaliana.
    Journal of Plant Physiology, 207, 42-50.

  • Kalimuthu P, Ringel P, Kruse T, Bernhardt P. (2016)
    Direct Electrochemistry of Nitrate Reductase from the Fungus Neurospora crassa.
    Biochimica et Biophysica Acta - Bioenergetics, 1857(9), 1506-1513.

  • Baillie, C. K., Kaufholdt, D., Karpinski, L. H., Schreiber, V., Hänsch, S., Evers, C., ... & Rennenberg, H. (2016).
    Detoxification of volcanic sulfur surplus in planta: Three different strategies of survival.
    Environmental and Experimental Botany, 126, 44-54.

  • Kaufholdt D, Baillie CK, Bikker R, Burkart V, Dudek CA, von Pein L, Rothkegel M, Mendel RR, Hänsch R (2016).
    The molybdenum cofactor biosynthesis complex interacts with actin filaments via molybdenum insertase Cnx1 as anchor protein in Arabidopsis thaliana.
    Plant Science 244, 8-18

  • Kanofsky K, Lehmeyer M, Schulze J, Hehl R (2016).
    Analysis of microbe-associated molecular pattern-responsive synthetic promoters.
    In: Hehl R (ed) Plant Synthetic Promoters: Methods and Protocols.
    Springer New York, New York, NY, Methods in Molecular Biology, 1482, 163-174.

  • Belkheir AK, Gaid M, Liu B, Hänsch R, Beerhues L (2016).
    Benzophenone Synthase and Chalcone Synthase Accumulate in the Mesophyll of Hypericum perforatum Leaves at Different Developmental Stages.
    Frontiers in Plant Science, 7, 921.

  • Paul S, Wildhagen H, Janz D, Teichmann T, Hänsch R, Polle A (2016).
    Tissue-and cell-specific cytokinin activity in Populus × canescens monitored by ARR5:: GUS reporter lines in summer and winter.
    Frontiers in Plant Science, 7, 652.

  • Bloem E, Haneklaus S, Hänsch R, Schnug E (2016).
    Evaluation of soil EDTA applications on crop performance and uptake of macro- and micronutrients by agricultural crops.
    Journal für Kulturpflanzen, 68(3), 63-71.

  • Plitzko B, Havemeyer A, Bork B, Bittner F, Mendel RR, Clement B (2016).
    Defining the Role of the NADH-Cytochrome-b5 Reductase 3 in the Mitochondrial Amidoxime Reducing Component Enzyme System.
    Drug Metabolism and Disposition, 44, 1617 - 1621.



  • Kaufholdt D, Baillie CK, Wille T, Lang C, Hallier S, Herschbach C, Rennenberg H, Mendel RR, Hänsch R (2015).
    Prospective Post-translational Regulation of Plant Sulfite Oxidase.
    Molecular Physiology and Ecophysiology of Sulfur, pp 179-187, Springer-Verlag

  • Arnoux P, Ruppelt C, Oudouhou F, Lavergne J, Siponen MI, Toci R, Mendel RR, Bittner F, Pignol D, Magalon A, Walburger A. (2015)
    Sulphur shuttling across a chaperone during molybdenum cofactor maturation.
    Nat Commun. 6

  • Magalon A and Mendel RR
    Biosynthesis and insertion of the molybdenum cofactor (2015).
    EcoSal Plus 2015; doi:10.1128/ecosalplus.ESP-0006-2013

  • Yang J, Giles LJ, Ruppelt C, Mendel RR, Bittner F, Kirk ML (2015).
    Oxyl and hydroxyl radical transfer in mitochondrial amidoxime reducing component-catalyzed nitrite reduction.
    J Am Chem Soc 137: 5276-5279.

  • Ringel, P., Probst, C., Dammeyer, T., Buchmeier, S., Jänsch, L., Wissing, J., ... & Kruse, T. (2015).
    Enzymatic characterization of recombinant nitrate reductase expressed and purified from Neurospora crassa.
    Fungal Genetics and Biology, 80, 10-18.



  • Mendel RR, Leimkühler S. (2014)
    The biosynthesis of the molybdenum cofactors.
    J Biol Inorg Chem. 2014 Jul 1.

  • Probst C, Ringel P, Boysen V, Wirsing L, Alexander MM, Mendel RR, Kruse T. (2014).
    Genetic characterization of Neurospora crassa molybdenum cofactor biosynthesis.
    Fungal Genet Biol. 66, 69 - 78

  • Ott, G., Reichmann, D., Remmler, C., Cascorbi, I., Bittner, F., Mendel, R.R., Kunze, T., Clement, B., and Havemeyer
    A.Nonsynonymous SNPs in the mitochondrial amidoxime reducing component (mARC) in healthy Caucasian and functional characterization of the genetic variants.
    Drug Metab. Dispos. 42; 718-725.

  • Bittner, F. (2014)
    Molybdenum metabolism in plants and crosstalk to iron.
    Front. Plant Sci. 5; 28. eCollection

  • Jakobs, H., Froriep, D., Havemeyer, A., Mendel, R.R., Bittner, F., and Clement, B. (2014)
    The mitochondrial amidoxime reducing component (mARC): involvement in metabolic reduction of N-oxides, oximes and N-hydroxyamidinohydrazones.
    Chem. Med. Chem. 9; 2381-2387.

  • Giles L.J., Ruppelt C., Yang J., Mendel R.R., Bittner F., Kirk M.L. 2014.
    Molybdenum Site Structure of MOSC Family Proteins.
    Inorganic Chemistry, Vol 53(18), pp. 9460-9462

  • Ott, G., Plitzko, B., Krischkowski, C., Reichmann, D., Bittner, F., Mendel, R.R., Kunze, T., Clement, B., and Havemeyer, A. (2014)
    Reduction of sulfamethoxazole hydroxylamine (SMX-HA) by the mitochondrial amidoxime reducing component (mARC).
    Chem. Res. Toxicol. 27; 1687-1695.

  • Bauch E, Reichmann D, Mendel RR, Bittner F, Manke AM, Kurz P, Girreser U, Havemeyer A, Clement B (2014).
    Electrochemical and mARC-Catalyzed Enzymatic Reduction of para-Substituted Benzamidoximes: Consequences for the Prodrug Concept "Amidoximes instead of Amidines".
    Chem. Med. Chem., 10(2), 360-367.

  • Urarte, E., Esteban, R., Moran, J.F., and Bittner, F. (2014)
    Established and proposed roles of xanthine oxidoreductase in oxidative and reductive pathways in plants. In: Reactive Oxygen and Reactive Nitrogen Species Signalling & Communication in Plants.
    edited by J.K. Gupta and A. Igamberdiev, Springer-Verlag

  • Randewig, D., Hamisch, D., Eiblmeier, M., Boedecker, C., Kreuzwieser, J., Mendel, R.R., Hänsch, R., Herschbach, C. , Rennenberg, H. (2014).
    Oxidation and reduction of sulfite contribute to susceptibility and detoxification of SO2 in Populus canescens leaves.
    Trees - Structure and Function, 28, 399-411

  • Reckwell, D., Hänsch, R., Schulze, J., Beerhues, L. (2014).
    Immunolocalization of biphenyl synthase in elicitor-treated cell cultures of Sorbus aucuparia.
    Acta Horticulturae 1056, 307-311

  • Schweinhuber SK, Meßerschmidt T, Hänsch R, Korte M, Rothkegel M (2014)
    Profilin Isoforms Modulate Astrocytic Morphology and the Motility of Astrocytic Processes.
    PLoS ONE, 10(1), e0117244.

  • Schulze Jutta (2014) Barley.
    In: A. Pratap and J. Kumar (eds.), Alien Gene Transfer in Crop Plants, Volume 2: Achievements and Impacts.
    Springer Science+Business Media, LLC 2014, p 85-120, DOI 10.1007/978-1-4614-9572-7_5,ISBN 978-1-4614-9571-0

  • Klocke, E.; Abel, S.; Schulze, J. (2014)
    In vitro storage and rooting of small pasque flower (Pulsatilla pratensis (L.) Mill. subsp. nigricans (Störck) Zamels.
    Academy of Sciences of Moldova Tipogr.. Chisinau pp.:194-196. ISSN/ISBN: 978-9975-56-194-5



  • Kaufholdt D., Gehl C., Geisler M., Jeske O., Voedisch S., Ratke C., Bollhöner B., Mendel R.R., Hänsch R. 2013.
    Visualization and quantification of protein interaction in the biosynthetic pathway of molybdenum cofactor in Arabidopsis thaliana.
    Journal of Experimental Botany, Vol 64, No. 7, pp. 2005-2016.

  • Kruse T. 2013.
    Offene Fragen des Neurospora crassa Molybdän-Metabolismus.
    Biospektrum, 1/2013, 28-29

  • Plitzko B., Ott G., Reichmann D., Henderson C.J., Wolf C.R., Mendel R.R., Bittner F., Clement B., Havemeyer A. 2013.
    The involvement of mitochondrial amidoxime reducing components 1 and 2 and mitochondrial cytochrome b5 in N-reductive matabolism in human cells.
    Journal of Biological Chemistry, 288, pp. 20228-20237.

  • Mendel R.R. 2013.
    Matabolism of molybdenum.
    Metal Ions in Life Science. 12:503-528

  • Mendel R.R. 2013.
    The molybdenum cofactor.
    Journal of Biological Chemistry, Vol 288(19): 13165-13172.

  • Ringel P., Krausze J., van den Heuvel J., Curth U., Pierik A.J., Herzog S., Mendel R.R., Kruse T. 2013.
    Biochemical charecterization of molybdenum cofactor-free nitrate reductase from Neurospora crassa.
    Journal of Biological Chemistry, Vol 288(20): 14657-14671.

  • Froriep D., Clement B., Bittner F., Mendel R.R., Reichmann D., Schmalix W., Havemeyer A. 2013.
    Activation of the anti-cancer agent upamostat by the mARC enzyme system.
    Xenobiotica . Vol. 43, No. 9, pp. 780-784.

  • Rajapakshe A., Astashkin A.V., Klein E.L., Reichmann D., Mendel R.R., Bittner F., Enemark J.H. 2013.
    Structural studies of the molybdenum center of mitochondrial amidoxime reducing component (mARC) by pulsed EPR spectroscopy and 17O-labeling.
    Biochemistry, Vol 50(41): 8813-8822.



  • Bittner, F. and Mendel, R.R. 2012.
    Molybdenum cofactor biosynthesis and crosstalk with iron-sulfur.
    Metals in Cells, EIBC Book, edited by V.Culotta and R.A. Scott

  • Bittner, F. 2012.
    MOSC family of Molybdo enzymes.
    Encyclopedia of Metalloproteins (online:

  • Mendel, Ralf R. 2012.
    Biosynthesis and distribution of the molybdenum cofactor.
    Encyclopedia of Metalloproteins (online:

  • Bauer, H., Ache, P., Lautner, S., Fromm, J., Hartung, W., Al-Rasheid, K.A.S., Sonnewald, S., Sonnewald, S., Kneitz, S., Lachmann, N., Mendel, R.R., Bittner, F., Hetherington, A.M., and Hedrich, R. 2012.
    The Stomatal Response to Reduced Relative Humidity Requires Guard Cell-Autonomous ABA Synthesis.
    Current Biology, Vol. 23, No 1, pp 53-57.

  • Zarepour M., Simon K., Wilch M., Nieländer U., Koshiba T., Seo M., Lindel T., Bittner F. 2012.
    Identification of superoxide production by Arabidopsis thaliana aldehyde oxidases AAO1 and AAO3.
    Plant Molekular Biology. Vol. 80(6), pp 659-671

  • Hamisch D., Randewig D., Schliesky S., Bräutigam A., Weber AP., Geffers R., Herschbach C., Rennenberg H., Mendel RR., Hänsch R. 2012.
    Impact of SO2 on Arabidopsis thaliana transcriptome in wildtype and sulfite oxidase knockout plants analyzed by RNA deep sequencing.
    New Phytologist.Vol 196(4), pages 1074-1085

  • Krompholz N., Krischkowski C., Reichmann D., Garbe-Schönberg D., Mendel RR., Bittner F., Clement B., Havemeyer A.
    The Mitochondrial Amidoxime Reducing Component (mARC) Is Involved in Detoxification of N-Hydroxylated Base Analogues.
    Chem Res Toxicol. 2012 Aug 27.

  • Mendel RR., Kruse T.
    Cell biology of molybdenum in plants and humans.
    Biochim Biophys Acta. 2012 Sep;1823(9):1568-79. Epub 2012 Feb 17.

  • Thomé R., Gust A., Toci R., Mendel R., Bittner F., Magalon A., Walburger A.
    A sulfurtransferase is essential for activity of formate dehydrogenases in Escherichia coli. 1.
    J Biol Chem.2012 Feb

  • Randewig D., Hamisch D., Herschbach C., Eiblmeier M., Gehl C., Jurgeleit J., Skerra J., Mendel R.R., Rennenberg H. & Hansch R.
    Sulfite oxidase controls sulfur metabolism under SO2 exposure in Arabidopsis thaliana (2012).
    Plant Cell Environ. 35,1: 100-115.

  • Lehrke, M., Rump, S., Heidenreich, T., Wissing, J., Mendel, R.R., and Bittner, F.
    Identification of persulfide-binding and disulfide-forming cysteines in the NifS-like domain of the molybdenum cofactor sulfurase ABA3 by cysteine scanning mutagenesis (2012).
    Biochem. J. 441: 823-832.

  • Koschmann J., Machens F., Becker M., Niemeyer J., Schulze J., Bülow L., Stahl D.J., Hehl R. 2012.
    Integration of Bioinformatics and Synthetic Promoters Leads to the Discovery of Novel Elicitor-Responsive cis-Regulatory Sequences in Arabidopsis thaliana.
    Plant Physiology, 160, 178-191.

  • Chizzali C., Gaid M.M., Belkheir A.K., Beuerle T., Hänsch R., Richter K., Flachowsky H., Peil A., Hanke M.V., Liu B., Beerhues L. 2012.
    Phytoalexin formation in fire blight-infected apple.
    Trees - Structure and Function, 1-8

  • Gaid M.M., Sircar D., Müller A., Beuerle T., Liu B., Ernst L., Hänsch R., Beerhues L. 2012.
    Cinnamate: CoA Ligase Initiates the Biosynthesis of a Benzoate-Derived Xanthone Phytoalexin in Hypericum calycinum Cell Cultures.
    Plant Physiology, 160, 1267-1280.

  • Driouch H., Hänsch R., Wucherpfennig T., Krull R., Wittmann C. 2012.
    Improved Enzyme Production by Bio-Pellets of Aspergillus niger: Targeted Morphology Engineering using Titanate Microparticles.
    Biotechnology and Bioengineering, 109, 462-471.

  • Chizzali C., Gaid M.M., Belkheir A.K., Hänsch R., Richter K., Flachowsky H., Peil A., Hanke M.V., Liu B., Beerhues L. 2012.
    Differential Expression of Biphenyl Synthase Gene Family Members in Fire-Blight-Infected Apple "Holstein Cox".
    Plant Physiology, 158, 864-875

  • Kassing M., Jenelten U., Schenk J., Hänsch R., Strube J. 2012.
    Combination of Rigorous and Statistical Modeling for Process Development of Plant-Based Extractions based on Mass Balances and Biological Aspects.
    Chemical Engineering and Technology 35, 109-132.



  • Mendel, R. R.,
    Zellbiologie der Pflanzen (2011),
    Lehrbuch, Ulmer Verlag Stuttgart

  • Mendel, R.
    Cell biology of molybdenum in plants (2011).
    Plant Cell Rep 30, 1787-1797

  • Hille, R., Mendel, R.R.
    Molybdenum in living systems (2011).
    Coord. Chem. Rev. 255, 991-992.

  • Mendel, R.R., Schwarz, G.:
    Molybdenum cofactor biosynthesis in plants and humans (2011).
    Coord. Chem. Rev. 255 1145-1158

  • Gehl C., Kaufholdt D., Hamisch D., Bikker R., Kudla J., Mendel R.R. & Hansch R.
    Quantitative analysis of dynamic protein-protein interactions in planta by a floated-leaf luciferase complementation imaging (FLuCI) assay using binary Gateway vectors (2011).
    Plant J, 67, 542-553.

  • Driouch H., Hansch R., Wucherpfennig T., Krull R. & Wittmann C.
    Improved enzyme production by bio-pellets of Aspergillus niger - targeted morphology engineering using titanate micro particles (2011) .
    Biotechnol. Bioeng. 2012;109: 462-471.

  • David F., Berger A., Hansch R., Rohde M. & Franco-Lara E.
    Single cell analysis applied to antibody fragment production with Bacillus megaterium: development of advanced physiology and bioprocess state estimation tools (2011).
    Microb Cell Fact, 10, 23.

  • Hille, R, Nishino, T., and Bittner, F. (2011)
    Molybdenum enzymes in higher organisms.
    Coord. Chem. Rev. 255: 1179-1205

  • Rajapakshe, A., Astashkin, A.V., Klein, E.L., Reichmann, D., Mendel,R.R., Bittner, F., Enemark, J.H.
    Structural studies of the molybdenum center of mitochondrial amidoxime reducing component (mARC) by pulsed EPR spectroscopy and 17O-labeling (2011).
    Biochemistry 50: 8813-8822

  • Gasber, A., Klaumann, S., Trentmann, O., Trampczynska, A., Clemens, S., Schneider, S., Sauer, N., Feifer, I., Bittner, F., Mendel, R.R., and Neuhaus, E. (2011).
    Identification of an Arabidopsis solute carrier critical for intracellular transport and interorgan allocation of molybdate.
    Plant Biol. 13: 710-718.

  • Kotthaus, J., Wahl, B., Schade, D., Gruenewald, S., Bittner, F., Mendel, R.R., and Clement, B.
    Involvement of the mitochondrial amidoxime reducing component (mARC) in the reduction of N-hydroxy-L-arginine and N-hydroxy-N-methyl-L-arginine (2011).
    Biochem. J. 433: 383-391.



  • Theisen, S., Hänsch, R., Kothe, L., Leist, U., Galensa, R. (2010)
    A fast and sensitive HPLC method for sulfite analysis in food based on a plant sulfite oxidase biosensor.
    Biosensors and Bioelectronics 26(1): 175-181.

  • Kruse, T., Gehl, C., Geisler, M., Lehrke, M., Ringel, P., Hallier, S., Hänsch R., and Mendel, R.R. (2010)
    Identification and biochemical characterization of molybdenum cofactor-binding proteins from Arabidopsis thaliana.
    J. Biol. Chem. 285(9):6623-35.

  • R. Hell and R.R. Mendel (eds.) (2010)
    Cell Biology of Metals and Nutrients, Plant Cell Monographs 17.
    Springer Press, Berlin Heidelberg

  • Bittner, F., and R.R. Mendel (2010).
    Cell biology of molybdenum. In: R. Hell and R.R. Mendel (eds.), Cell Biology of Metals and Nutrients, Plant Cell Monographs 17,
    Springer Press, Berlin Heidelberg

  • Zarepour, M., Kaspari, K., Stagge, S., Rethmeier, R., Mendel, R. R., Bittner, F. (2010)
    Xanthine dehydrogenase AtXDH1 from Arabidopsis thaliana is a potent producer of superoxide anions via its NADH oxidase activity.
    Plant. Mol. Biol. 72: 301-310.

  • Teschner, J., Lachmann, N., Schulze, J., Geisler, M., Selbach, K., Santamaria-Araujo, J., Balk, J., Mendel, R. R., Bittner, F. (2010)
    A novel role for Arabidopsis mitochondrial ABC transporter ATM3 in molybdenum cofactor biosynthesis.
    Plant Cell. 22(2):468-80.



  • Scheere, U., Hänsch, R. Mendel, R.-R., Kopriva, S., Rennenberg, H. and Herschbach, C. (2009)
    Sulphur flux through the sulphate assimilation pathway is differently controlled by adenosine 5’-phosphosulphate reductase under stress and in transgenic poplar plants overexpressing γ-ECS, SO or APR.
    J Exp Bot. 61(2): 609-622.

  • Byrne, R. S., Hänsch, R., Mendel, R. R. and Hille R. (2009)
    The oxidative half-reaction of Arabidopsis thaliana sulfite oxidase. Generation of superoxide by a peroxisomal enzyme.
    J Biol Chem. (51):35479-84.

  • Popko, J., Mendel, R.-R., Polle, A. Hänsch, R. and Teichmann, T. (2009)
    The Role of Abscisic Acid and Auxin in the Response of Poplar to Abiotic Stress,
    Plant Biology. 12(2):242-58.

  • Arend, M., Hänsch, R., Schnitzler, J.-P., Lange, T., Renneberg, H., Grill, E., Ehlting, B. and Fromm, J. (2009)
    Expression of the Arabidopsis mutant abi1 gene alters ABA sensitivity, stomatal development and growth morphology in Grey poplars (Populus x canescens (Ait.) Sm.),
    Plant Physiol. 151(4):2110-9.

  • Gehl, C., Waadt, R., Kudla, J., Mendel, R.-R. and Hänsch, R. (2009)
    New GATEWAY-vectors for high throughput analyses of protein-protein interactions by Bimolecular Fluorescence Complementation,
    Molecular Plant 2 (5), pp. 1051-1058

  • Cinege, G., Louis, S., Hansch, R. and Schnitzler, J. P. (2009)
    Regulation of isoprene synthase promoter by environmental and internal factors.
    Plant Molecular Biology 69 (5), pp. 593-604

  • Schwarz, G., R.R. Mendel and M. Ribbe:
    Molybdenum cofactors, enzymes and pathways (2009).
    Nature 460, 839-847

  • Hänsch, R., and R.R. Mendel:
    Physiological functions of mineral micronutrients (Cu, Zn, Mn, Fe, Ni, Mo, B, Cl) (2009).
    Curr. Opinion in Plant Biology 12, 259 - 266.

  • Mendel, R.R.:
    Cell Biology of Molybdenum (2009).
    BioFactors 35, 429 - 434

  • Grünewald, S., Wahl, B., Bittner, F., Hungeling, H., Kanzow, S., Kotthaus, J., Schwering, U., Mendel. R.R., and B. Clement (2009)
    The fourth molybdenum containing human enzyme mARC: cloning and reduction of N-dydroxylated structures.
    J. Med. Chem. 51, 8173 - 8177.

  • Raab, S., Drechsel, G., Zarepour, M., Hartung, W., Koshiba, T., Bittner, F., Hoth, S. (2009)
    Identification of a novel E3 ubiquitin ligase that is required for suppression of premature senescence in Arabidopsis.
    Plant J. 59:39-51.



  • Teichmann, T., Bolu-Arianto, W. H., Olbrich, A., Langenfeld-Heyser, R., Gobel, C., Grzeganek, P., Feussner, I., Hansch, R. and Polle, A. (2008)
    GH3::GUS reflects cell-specific developmental patterns and stress-induced changes in wood anatomy in the poplar stem.
    Tree Physiol 28, 1305-15.

  • Anke, S., Gonde, D., Kaltenegger, E., Hänsch, R., Theuring, C. and Ober, D. (2008)
    Pyrrolizidine alkaloid biosynthesis in Phalaenopsis orchids: developmental expression of alkaloid-specific homospermidine synthase in root tips and young flower buds.
    Plant Physiol 148, 751-60.

  • Melhorn V, Matsumi K, Koiwai H, Ikegami K, Okamoto M, Nambara E, Bittner F, Koshiba T (2008);
    Transient expression of AtNCED3 and AAO3 genes in guard cells causes stomatal closure in Vicia fab.a
    J. Plant Res. 121; 125-131

  • Wollers, S., Heidenreich, T., Kraft, C., Zhao, Y., Mendel, R.R., and Bittner, F. (2008).
    Binding of sulfurated molybdenum cofactor to the C-terminal domain of ABA3 from Arabidopsis thaliana provides insight into the mechanism of molybdenum cofactor sulfuration.
    J. Biol.Chem. 283, 9642-9650.



  • Schulze J. (2007)
    Improvements in cereal tissue culture by thidiazuron: A review.
    Fruit, Vegetable and Cereal Science and Biotechnology 1(2) 64-79

  • Sharma V.K., Hänsch R., Mendel R.R., J. Schulze (2007).
    Node-derived cultures with high morphogenic competence in barley and wheat.
    Plant Cell Tissue and Organ Culture 88, 21-33.

  • Kruse, J., Kopriva, S., Hänsch, R., Krauss, G. J., Mendel, R. R. and Rennenberg, H. (2007)
    Interaction of Sulfur and Nitrogen Nutrition in Tobacco (Nicotiana tabacum) Plants: Significance of Nitrogen Source and Root Nitrate Reductase.
    Plant Biol (Stuttg) 9, 638-46

  • Hänsch, R., Lang, C., Rennenberg, H. and Mendel, R. R. (2007)
    Significance of Plant Sulfite Oxidase.
    Plant Biol (Stuttg) 9, 589-595

  • Magalon, A., and R.R. Mendel (2007).
    Chapter, Biosynthesis and insertion of the molybdenum cofactor.
    A. Böck, R. Curtiss III, J. B. Kaper, F. C. Neidhardt, T. Nyström, K. E. Rudd, and C. L. Squires (ed.), EcoSal-Escherichia coli and Salmonella: cellular and molecular biology. [Online.] ASM Press, Washington, D.C.

  • Melhorn, V., K. Matsumi, H. Koiwai, K. Ikegami, M. Okamoto, E. Nambara, F. Bittner and T. Koshiba (2007).
    Transient expression of AtNCED3 and AAO3 genes in guard cells causes the stomatal closure in Vicia faba L.
    J. Plant Res. 121 (1): 125-131.

  • Lang, C, Popko, J, Witz, M, Hell, R, Herschbach, C, Kreuzwieser, J, Renneberg, H, Mendel, RR, Hänsch, R (2007)
    Sulphite oxidase as key enzyme for protecting plants against sulphur dioxide.
    Plant, Cell Environ. 30, 447 -455.

  • Ehlting, B., Dluzniewska, P., Dietrich, H., Selle, A., Teuber, M., Hänsch, R., Nehls, U., Polle, A., Schnitzler, J. P., Rennenberg, H. and Gessler, A. (2007)
    Interaction of nitrogen nutrition and salinity in Grey poplar (Populus tremula x alba).
    Plant Cell Environ 30, 796-811

  • Behnke, K., Ehlting, B., Teuber, M., Bauerfeind, M., Louis, S., Hänsch, R., Polle, A., Bohlmann, J. and Schnitzler, J. P. (2007)
    Transgenic, non-isoprene emitting poplars don't like it hot.
    Plant J 51, 485-99

  • Mendel, R.R. (2007)
    Biology of the Molybdenum cofactor.
    J. Expt. Bot. 58, 2289 - 2296.

  • Rebeille, F., S. ravanel, A. marquet, R.R. Mendel, A.G. Smith, M.J. Warren (2007).
    Roles of vitamins B5, B8, B9, B12 and molybdenum cofactor at cellular and organismal levels. Metal and cofactor insertion.
    Nat. Prod. Rep. 24, 949-962.

  • Webb, M.E., A. Marqut, R.R. Mendel, F. Babeille, A.J. Smith (2007).
    Elucidating biosynthetic pathways for vitamins and cofactors.
    Nat. Prod. Rep. 24, 988-1008.

  • Holliday, G.L., J.M. Thornton, A. marquet, A.G. Smith, F. Rabeille, R.R. Mendel, H.L. Schubert, A.D. Lawrence, M.J. Warren (2007).
    Evolution of enzymes and pathways for the biosynthesis of cofactors.
    Nat. Prod. Rep. 24, 972 - 987.

  • Mendel, R.R., A.G. Smith, A. Marquet, M.J. Warren (2007).
    Metal and cofactor insertion.
    Nat. Prod. Rep. 24, 963-971.



  • Nurhayati N., Anke S., Gonde D., Hänsch R., Theuring C. and Ober D. (2006)
    Developmental expression of alkaloid-specific homospermidine synthase in Phalaenopsis - an old feature within monocots?
    The Plant Cell (submitted)

  • Sharma V. K., Monostori T., Gobel C., Hänsch R., Bittner F., Wasternack C., Feussner I., Mendel R.-R., Hause B. and Schulze J. (2006)
    Transgenic barley plants overexpressing a 13-lipoxygenase to modify oxylipin signature.
    Phytochemistry 67: 264-76.

  • Hänsch R. (2006)
    Sulfur Transport and Assimilartion in Plants in the Post Genomic Era - Book Review.
    J. of Plant Physiol. 163: 1062

  • Lang, C., Schulze, J., Mendel, R.R., Hänsch, R. (2006).
    HaloTag - a new versatile reporter gene system in plant cells.
    J. Expt. Bot. 57, 2985-2992.

  • Hänsch R, Lang C, Riebeseel E, Lindigkeit R, Gessler A, Rennenberg H and Mendel RR (2006).
    Plant sulfite oxidase as novel producer of H2O2. Combination of enzyme catalysis with a subsequent non-enzymatic reaction step.
    J. Biol. Chem. 281, 6884-6888

  • Llamas, A., Otte, T., Multhaupt, G., Mendel, R.R., Schwarz,G. (2006).
    The mechanism of nucleotide-assisted molybdenum insertion into molybdopterin: A Novel route towards metal cofactor assembly.
    J. Biol. Chem. 281, 18343-40.

  • Fischer K, Llamas A, Tejada-Jimenez M, Schader N, Kuper J, Ataya FS, Galvan A, Mendel RR, Fernandez E, Schwarz G. (2006)
    Function and structure of the molybdenum cofactor carrier protein MCP from Chlamydomonas reinhardtii.
    J Biol Chem. 281, 10186-94.

  • Havemeyer A, Bittner F, Wollers S, Mendel R, Kunze T, Clement B.
    Identification of the missing component in the mitochondrial benzamidoxime prodrug converting system as a novel molybdenum enzyme (2006).
    J.Biol.Chem. 281, 34796-802.

  • Hänsch R. und Mendel R.-R. (2006)
    Sulfite Oxidation in Plants. (iAdvances in Photosynthesis and Respiration).
    Photosynthesis Research. 83(1): 101-105.

  • Schwarz, G. and R.R. Mendel.
    Molybdenum Cofactor Biosynthesis and Molybdenum Enyzmes.
    Ann. Rev. Plant Biol. (2006), 57, 623-47.

  • Mendel, R.R., Bittner, F. (2006).
    Cell biology of molybdenum.
    Biochim. Biophys. Acta 1763, 621 - 635.



  • Brian L. Hood, Craig Hemann, Meita Fulton, Günter Schwarz, Robert Hänsch, Ralf R. Mendel, Martin L. Kirk, and Russ Hille (2005).
    Spectroscopic and Kinetic Studies of Arabidopsis thaliana Sulfite Oxidase: Nature of the Redox-active Orbital and Electronic Structure Contributions to Catalysis (2005).
    J.Am.Chem.Soc. 127, 16567-77.

  • Hehl R., Grohmann J., Fuljahn S., Mendel R.-R., Cerff, R. and Hänsch R. (2005)
    Genetic approaches to investigate the high CO2 response of plants during soil flooding.
    Recent Res. Devel. Soil Sci. 1: 37-49

  • Jost R, Altschmied A, Bloem E, Bogs J, Gershenzon J, Haehnel U, Haensch R, Hartmann T, Kopriva; S, Kruse C, Mendel RR, Papenbrock J, Reichelt M, Rennenberg H, Schnug E, Schmidt A, Textor S, Tokuhisa J, Wachter A, Wirtz M, Rausch T and Hell R (2005)
    Expression profiling of metabolic genes in response to methyl jasmonate reveals regulation of genes of primary and secondary sulfur-related pathways in Arabidopsis thaliana.
    Photos. Research 86, 491-508

  • Jost R, Altschmied A, Bloem E, Bogs J, Gershenzon J, Haehnel U, Haensch R, Hartmann T, Kopriva; S, Kruse C, Mendel RR, Papenbrock J, Reichelt M, Rennenberg H, Schnug E, Schmidt A, Textor S, Tokuhisa J, Wachter A, Wirtz M, Rausch T and Hell R (2005)
    Expression profiling of metabolic genes in response to methyl jasmonate reveals regulation of genes of primary and secondary sulfur-related pathways in Arabidopsis thaliana.
    Photos. Research 86, 491-508

  • Mendel, R.R.
    Molybdenum: biological activity and metabolism.
    Dalton Trans. (2005), 3404 - 3409.

  • Hänsch R. und Mendel R.-R. (2005)
    Sulfite oxidation in peroxisomes.
    Photosynth. Research 86: 337-343.

  • Andrei V. Astashkin, Brian L. Hood, Changjian Feng, Russ Hille, Ralf R. Mendel, Arnold M. Raitsimring, John H. Enemark (2005).
    Structures of the Mo(V) Forms of Sulfite Oxidase from Arabidopsis thaliana by Pulsed EPR Spectroscopy.
    Biochemistry 44, 13274-81

  • Sharma, V.K., Monostori, T., Hause, B., Maucher, H., Göbel, C., Hornung, E., Hänsch, R., Bittner, F., Wasternack, C., Feussner, I., Mendel, R.R., Schulze, J.
    Genetic transformation of barley to modify expression of a 13-lipoxygenase
    Acta Biologica Szegediensis 49 (1-2), 33-34 (2005)

  • Sharma VK, Hänsch R, Mendel RR, Schulze J. (2005)
    Mature embryo axis-based high frequency somatic embryogenesis and plant regeneration in barley (Hordeum vulgare L.) with long term maintenance of regenerability and less genotype dependency.
    Journal of Experimental Botany 56: 1913-1922

  • Sharma VK, Hänsch R, Mendel RR, Schulze J. (2005).
    Interaction of picloram and thidiazuron for high frequency plant regeneration in elite cultivars of wheat (Triticum aestivum L.) with long-term retention of morphogenecity using meristematic shoot segments.
    Plant Breeding 124: 242-246

  • Fischer K, Barbier GG, Hecht H-J, Mendel RR, Campbell WH, Schwarz G. (2005)
    Crystal Structure of the Yeast Nitrate Reductase Molybdenum Domain Provides Insight into Eukaryotic Nitrate Assimilation.
    Plant Cell 17:1167-79

  • Heidenreich T, Wollers S, Mendel RR, Bittner F. (2005)
    Characterization of the NifS-like domain of ABA3 from arabidopsis thaliana provides insight into the mechanism of molybdenum cofactor sulfuration.
    J. Biol. Chem. 280, 4213-8 Epub 2004 Nov 22

  • Sharma, V. K., Hänsch, R., Mendel R.R. and J. Schulze (2005)
    Seasonal effect on tissue culture response and plant regeneration frequency from non-bombarded and bombarded immature scutella of barley (Hordeum vulgare L.) harvested from controlled environment.
    Plant Cell Tissue and Organ Culture, 81,19-26



  • Godber, B.L.J., Schwarz, G., Mendel, R.R., Lowe, D.J., Bray, R.C., Eisenthal, R., and Harisson, R. 2004
    Molecular Characterization of Human Xanthine Oxidase: The enzyme is grossly deficient in molybdenum and substantially deficient in iron-sulfur centres.
    Biochem. J. 388, 501-508

  • Llamas, A., Mendel. R.R., and Schwarz, G.* (2004)
    Synthesis of adenylated molybdopterin: an essential step for molybdenum insertion.
    J. Biol. Chem. , 279, 55241-6.

  • Leimkühler S, Stockert AL, Igarashi K, Nishino T, Hille R.
    The role of active site glutamate residues in catalysis of rhodobacter capsulatus xanthine dehydrogenase.
    J Biol Chem. 2004 Sep 24;279(39):40437-44. Epub 2004 Jul 20.

  • Linking the Synapse to the Cytoskeleton: a Breath-taking Role for Microfilaments.
    Review Neuroreports 2004 Jul 19;15(10):1535-8.

  • Structure of molybdopterin-bound Cnx1G domain links molybdenum and copper metabolism.
    Nature. 2004 Aug 12;430(7001):803-6.

  • A highly efficient plant regeneration system through multiple shoot differentiation from commercial cultivars of barley ( Hordeum vulgare L.) using meristematic shoot segments excised from germinated mature embryos.
    Plant Cell Reports 23: 9-16

  • Rescue of lethal molybdenum cofactor deficiency by a biosynthetic precursor from Escherichia coli.
    Hum. Mol. Gen. 13: 1249-55

  • Peroxisomal localization of sulfite oxidase separates it from chloroplast-based sulfur assimilation.
    Plant Cell Physiol. 45, 1889-94.

  • Studies on the mechanism of action of xanthine oxidase.
    J. Inorg. Biochem.: 2004 May;98(5):841-8.

  • Evidence for the physiological role of a rhodanese-like protein for the biosynthesis of the molybdenum cofactor in humans.
    Proc. Natl. Acad. Sci. U S A. 2004 101: 5946-5951

  • Schrader N, Kim EY, Winking J, Paulukat J, Schindelin H, Schwarz G. 2004
    Biochemical characterization of the high affinity binding between the glycine receptor and gephyrin.

  • Santamaria Araujo, J.A., Fischer, B. Otte, T., Nimtz, M, Wray, V, Mendel, R.R. and Schwarz, G*. (2004)
    The structure of the sulfur- and molybdenum-free pyranopterin precursor of the molybdenum cofactor.

  • Katharina Nowak, Nora Luniak, Stephanie Meyer, Jutta Schulze, Ralf R. Mendel and Robert Hänsch. (2004)
    Fluorescent proteins in poplar: A useful tool to study promoter function and protein localization.

  • Hesberg, C., Hänsch, R., Mendel, R.R., and Bittner, F. (2004)
    Tandem orientation of duplicated xanthine dehydrogenase genes from Arabidopsis thaliana: differential gene expression and enzyme activities,

  • S. Meyer, K. Nowak, V. K. Sharma, J. Schulze, R. R. Mendel and R. Hänsch. (2004)
    Vectors for RNAi-technology



  • Giesemann, T., Schwarz, G., Navrotzki, R., Berhörster, K., Rothkegel, M., Schlüter, K., Schrader, N., Schindelin, H., Mendel, R.R., Kirsch, J., and Jockusch, B. 2003.
    Profilin and Mena link the postsynaptic scaffold protein gephyrin to the microfilament system.
    J. Neurosci. 23: 8330-8339

  • Wettern, M. Hamacher, J, and Schulz, M. (2003)
    Ubiquitin in der Wirt-Pathogen-Interaktion höherer Pflanzen.
    BIOforum 3, 129-131.

  • Silke Leimkühler, Andrea Freuer, Jose Angel Santamaria Araujo, K.V.Rajagopalan and Ralf R.Mendel.2003.
    Mechanistic Studies of Human Molybdopterin Synthase Reaction and Characterization of Mutants Identified in Group B Patients of Molybdenum Cofactor Deficiency.
    J. Biol. Chem.: 278: 26127-26134

  • Leimkühler, S., Hodson, R., George, G. N., and Rajagopalan, K.V. (2003)
    Recombinant Rhodobacter capsulatus xanthine dehydrogenase, a useful model system for the characterization of protein variants leading to xanthinuria I in humans.
    J. Biol. Chem. 278: 20802-20811

  • Aguey-Zinsou, K.F., Bernhardt, P.V., and Leimkühler, S. (2003)
    Protein film voltammetry of Rhodobacter capsulatus xanthine dehydrogenase.
    J. Am. Chem. Soc. 125: 15352-15358

  • Monostori, T., Schulze, J., Sharma, V.K., Maucher, H., Wasternack, C. and B. Hause:
    Novel plasmid vectors for homologous transformation of barley (Hordeum vulgare L.) with JIP23 cDNA in sense and antisense orientation.
    Cereal Research Communications 31, 17-24 (2003)

  • Kruse J., Hetzger I., Hänsch R., Mendel R.-R., and Rennenberg H. (2003)
    Elevated pCO2 affects C and N Metabolism in Wild Type and Transgenic Tobacco Exhibiting Altered C/N Balance in Metabolite Analysis.
    Plant Biol. 5: 540-545.

  • Hänsch R, Kurz T., Schulze, J., Cerff, R., Mendel R. R. and Hehl R. (2003)
    Light dependent and inducible gene expression systems for poplar.
    Planta 218: 79-86..

  • Schrader, N., Fischer, K., Theis, K., Mendel, R.R., Schwarz, G., Kisker, C. 2003.
    The Crystal Structure of Plant Sulfite Oxidase Provides Insights into Sulfite Oxidation in Plants and Animals.
    Structure, 11, 1251-1263

  • Garattini, E., Mendel, R., Romao, M.J., Wright, R., Terao, M. (2003).
    Mammalian molybdo-flavoenzymes, an expanding family of proteins: structure, genetics, regulation, function and pathophysiology.
    Biochem. J. 372, 15-32.

  • Hamacher, J., Wettern, M. and Schulz, M. (2003)
    Ubiquitination of TMV coat protein aggregates in infected tobacco leaves.
    J. Phytopathol. 151, 652-659.

  • Robert Hänsch, Tobias Kurz, Jutta Schulze, Ralf R. Mendel, Rüdiger Cerff, Reinhard Hehl, 2003.
    Anaerobic induction of the maize GapC4 promoter in poplar leaves requires light and high CO2,
    Planta, 218(1):79-86.

  • M. Stoimenova, R. Hänsch, R. Mendel, H. Gimmler, W.M. Kaiser, 2003.
    The role of nitrate reduction in the anoxic metabolism of roots I. Characterization of root morphology and normoxic metabolism of wild type tobacco and a transformant lacking nitrate reductase.
    Plant and Soil 253: 145-153

  • Guse, A., Stevenson,C.E.M., Kuper, J., Buchanan, G., Schwarz, G., Giordano, G., Magalon, A., Mendel, R.R., Lawson, D.M. and Palmer, T. 2003.
    Biochemical and structural analysis of the molybdenum cofactor biosynthesis protein MobA.
    J. Biol. Chem. 278: 25302-25307

  • Kuper, J., Meyer zu Berstenhorst, S., Vödisch, B., Mendel, R.R., Schwarz, G. and Boxer, D.H. (2003)
    In vivo detection of molybdate-binding proteins using a competition assay with ModE in Escherichia coli.
    FEMS Microbiol. Lett. 218, 187-193

  • Kuper, J., Winking, J., Hecht, H.-J., Mendel, R.R., Schwarz, G. (2003)
    The molybdenum cofactor biosyntethic protein domain Cnx1G: Phosphate anchoring of molybdopterin and mutant analysis define the active site.
    Arch Biochem Biophys 411, 36-46

  • Hänsch R. Mendel R.R., Cerff R. and Hehl R.
    Light Dependent Anaerobic Induction of the Maize GapC4 Promoter in Arabidopsis thaliana and Tobacco.
    Annals of Botany 91, 149-154.



  • Moll S., Anke S., Kahmann U., Hänsch R., Hartmann T., and Ober D.
    Cell-Specific Expression of Homospermidine Synthase, the Entry Enzyme of the Pyrrolizidine Alkaloid Pathway in Senecio vernalis, in Comparison with Its Ancestor, Deoxyhypusine Synthase.
    Plant Physiol. 130: 47-57

  • Kruse J., Hetzger I., Hänsch R., Mendel R.-R., Walch-Liu P., Engels C., and Rennenberg H. (2002)
    Elevated pCO2 favours nitrate reduction in the roots of wild-type tobacco (Nicotiana tabacum cv. Gat.) and significantly alters N-metabolism in transformants lacking functional nitrate reductase in the roots.
    J. Exp. Bot. 53: 2351-2367.

  • Mendel R.R., and Hänsch R. (2002).
    Molybdoenzymes and the molybdenum cofactor in plants.
    J. Exp. Bot. 53 (375) 1-10.

  • Lee, H.J., Adham, I.M., Schwarz, G., Kneussel, M., Sass, J.O., Engel, W., Reiss, J. (2002)
    Molybdenum cofactor-deficient mice resemble the phenotype of human patients.
    Hum Mol Genet 11, 3309-17

  • Hänzelmann, P., Schwarz, G., and Mendel, R.R. (2002)
    Human Molybdenum Cofactor Biosynthesis: Functional Characterization of Alternative mocs1 Splice Forms Involved in Precursor Z Synthesis.
    J Biol Chem 277, 18303-12

  • Mendel, R. R., and Schwarz, G. (2002).
    Biosynthesis and Molecular Biology of the Molybdenum Cofactor (Moco).
    In Molybdenum and Tungsten. Their Roles in Biological Processes, A. Sigel and H. Sigel, eds. (New York: M. Dekker). 317-368



  • Reiss, J., Gross-Hardt,S., Christensen, E., Schmidt, P., Mendel, R.R., and Schwarz, G. (2001).
    A mutation in the gene for the neurotransmitter receptor-clustering protein gephyrin causes a novel form of molybdenum cofactor deficiency.
    Amer. J. Human Genet. 68, 208-213

  • Hänsch R, Gómez Fessel D, Witt C, Hesberg C, Hoffmann G, Walch-Liu P, Engels E, Kruse J, Rennenberg H, Kaiser WM and Mendel RR

    J. Expt. Bot. 52, 1-8 (2001)

  • Buchanan, G., Kuper, J., Mendel, R.R., Schwarz, G. and Palmer, T. (2001):
    Characterisation of the mob locus of Rhodobacter sphaeroides WS8: mobA is the only gene required for molybdopterin guanine dinucleotide synthesis".
    Arch. Microbiol. 176, 62-68

  • Gutzke, G., Fischer, B., Mendel, R. R., and Schwarz, G. (2001)
    Thiocarboxylation of molybdopterin synthases provides evidences for the mechanism of the formation of dithiolenes in metal-binding pterins.
    J Biol Chem 276, 36268-74

  • Schwarz, G., Schrader, N., Mendel, R. R., Hecht, H. J., and Schindelin, H. (2001).
    Crystal Structures of Human Gephyrin and Plant Cnx1 G domains - Comparative Analysis and Functional Implications.
    J Mol Biol 312, 405-418

  • Bittner, F., Oreb, M., and Mendel, R.R. (2001).
    ABA3 is a molybdenum cofactor sulfurase required for activation of aldehyde oxidase and xanthine dehydrogenase in Arabidopsis thaliana.
    J. Biol. Chem. 276; 40381-40384

  • Eilers, T., Schwarz, G., Brinkmann, H. Witt, C., Richter, T., Nieder, J., Hille, R., Hänsch, R., and Mendel, R.R. (2001)
    Identification and biochemical characterization of Arabidopsis thaliana sulfite oxidase: A new player in plant sulfur metabolism.
    J Biol Chem 276, 46989-94



  • Kuper, J., Palmer, T., Mendel, R. R., and Schwarz, G. (2000).
    Mutations in the molybdenum cofactor biosynthetic protein Cnx1G from Arabidopsis thaliana define functions for molybdopterin bind, Mo-insertion and molybdenum cofactor stabilization.
    Proc Natl Acad Sci USA 97 6475-6480.

  • Kappler, U., Bennett, B., Rethmeier, J., Schwarz, G., Deutzmann, R., McEwan, A. G., and Dahl, C. (2000).
    Sulfite : Cytochrome c oxidoreductase from Thiobacillus novellus - Purification, characterization, and molecular biology of a heterodimeric member of the sulfite oxidase family.
    J Biol Chem 275, 13202-13212

  • Schwarz, G., Schulze, J., Bittner, F., Eilers, T., Kuper, J., Bollmann, G., Nerlich, A., Brinkmann, H., and Mendel, R.R. (2000).
    The molybdenum cofactor-biosynthetic protein Cnx1 complements molybdate-repairable mutants, transfers molybdenum to the metal-binding pterin and is associated with the cytoskeleton.
    The Plant Cell 12, 2455-2472



  • Mendel, R.R. (1999).
    The role of the molybdenum cofactor in humans.
    BioFactors (2000) 11, 147.

  • Schwarz, G., Stallmeyer, B., Reiss, J., and Mendel, R. R. (1999).
    The Molybdopterin cofactor: Biosynthesis and deficiencies in humans.
    Pteridines 10, 67-68.

  • Leimkühler, S., S. Angermüller, G. Schwarz, R.R. Mendel and W. Klipp (1999):
    Activity of the molybdopterin-containing xanthine dehydrogenase of Rhodobacter capsulatus can be restored by high molybdenum concentrations in a moeA mutant defective in molybdenum cofactor biosynthesis.
    J. Bacteriol. 181, 5930-5939.

  • Mendel, RR; Schwarz, G.
    Molybdoenzymes and molybdenum cofactor in plants.
    Critical Reviews In Plant Sciences, 1999, V18 N1:33-69.

  • Schledzewski, K, H. Brinkmann and Ralf R.Mendel .
    Phylogenetic analysis of components of the eukaryotic vesicle transport system reveal a common origin of the adaptor protein complexes AP1/2/3 and the F-subcomplex of the coatomer COPI.
    J. Molec. Evolution. 48(6):770-8.

  • Stallmeyer, B., Schwarz, G., Schulze, J., Nerlich, A., Reiss, J., Kirsch, J., and Mendel, R. R. (1999).
    The neurotransmitter receptor-anchoring protein gephyrin reconstitutes molybdenum cofactor biosynthesis in bacteria, plants, and mammalian cells.
    Proc Natl Acad Sci U S A 96, 1333-8.

  • Stallmeyer, B., G. Drugeon, J. Reiss, A.-L. Haenni and R. R. Mendel.
    The human molybdopterin synthase gene: 1. Identification of a bicistronic transcript with overlapping reading frames.
    Amer. J. Human Genet. 1999

  • J. Reiss, N.Cohen, B. Stallmeyer. R.R. Mendel , C. Dorche.
    The human molybdopterin synthase gene: 2. Genomic structure and mutations in molybdenum cofactor deficiency type B.
    Amer. J. Human Genet. 1999

  • Schunn, G., von Kampen, J., Nieländer, U. und Wettern, M. (1999)
    Identification and characterization of ubiquitin-activating and -conjugating enzymes from Chlamydomonas reinhardtii.
    Plant Biol. 1, 90-95.



  • Pauk, J; Hänsch, R; Schwarz, G; Nerlich, A; and others.
    Genetic transformation of wheat (Triticum aestivum L) in Hungary.
    Növénytermelés, 1998 JUN, V47 N3:241-251.

  • Reiss, J; Cohen, N; Dorche, C; Mandel, H; and others.
    Mutations in a polycistronic nuclear gene associated with molybdenum cofactor deficiency.
    Nature Genetics, 1998 SEP, V20 N1:51-53.

  • Witte, C. P., Igeno, M. I., Mendel, R., Schwarz, G., and Fernandez, E. (1998).
    The Chlamydomonas reinhardtii MoCo carrier protein is multimeric and stabilizes molybdopterin cofactor in a molybdate charged form.
    FEBS Lett 431, 205-209

  • Mendel, R.R., H.Brinkmann, K. Greger, A. Nerlich, J. Nieder, K. Schledzewksi, J. Schulze, G. Schwarz, B. Stallmeyer:
    Molybdenum cofactor biosynthesis in plants and humans. In: W. Pfleiderer, H. Rokos (Eds.) Chemistry and Biology of pteridines and folates.
    Blackwell Science 1997, pp. 681-692.

  • Hänsch, R; Mendel, RR; Schulze, J.
    A rapid and sensitive method to evaluate genotype specific tolerance to phosphinothricin-based selective agents in cereal transformation.
    Journal Of Plant Physiology, 1998 MAR, V152 N2-3:145-150.

  • Leimkühler, S., Kern, M., Solomon, P. S., McEwan, A. G., Schwarz, G., Mendel, R. R., and Klipp, W. (1998).
    Xanthine dehydrogenase from the phototrophic purple bacterium Rhodobacter capsulatus is more similar to its eukaryotic counterparts than to prokaryotic molybdenum enzymes.
    Mol Microbiol 27, 853-869



  • Nieder J., Stallmeyer B., Brinkmann H., Mendel R.R.
    Molybdenum cofactor biosynthesis: identification of A. thaliana cDNAs homologous to the E.coli sulfotransferase MoeB. In: Cram, WJ, De Kok LJ, Stulen I, Brunold C, Rennenberg H (eds) Sulphur metabolism in higher plants: molecular, ecophysiological and nutritional aspects.
    SPB Academic Publishers, Amsterdam.1997

  • Mendel, RR.
    Molybdenum cofactor of higher plants: biosynthesis and molecular biology.
    Planta, 1997 DEC, V203 N4:399-405.

  • Schwarz, G; Boxer, DH; Mendel, RR.
    Molybdenum cofactor biosynthesis - The plant protein Cnx1 binds molybdopterin with high affinity.
    JBC, 1997 OCT 24, V272 N43:26811-26814.

  • Wettern, M., Fooladi, D., Tacke, R. und Syldatk, C. (1997)
    Biotechnologie mit Algen: Einsatz von Mikroalgen in der chemischen Synthese.
    Carolo-Wilhelmina Mitt. 32, 34-37 (ISSN 0934-6708).



  • Koprek T; Hänsch R; Nerlich A; Mendel RR; and others.
    Fertile transgenic barley of different cultivars obtained by adjustment of bombardment conditions to tissue response.
    Plant Science, 1996 Sep 13, V119 N1-2:79-91.

  • Hänsch R; Koprek T; Heydemann H; Mendel RR and others.
    Electroporation-mediated transient gene expression in isolated scutella of Hordeum vulgare.
    Physiologia Plantarum, 1996 Sep, V98 N1:20-27.

  • Köhler U; Mendel RR; Cerff R; Hehl R.
    A promoter for strong and ubiquitous anaerobic gene expression in tobacco.
    Plant Journal, 1996 Jul, V10 N1:175-183.

  • Köhler U; Donath M; Mendel RR; Cerff R; and others.
    Intron-specific simulation of anaerobic gene expression and splicing efficiency in maize cells.
    Molecular & General Genetics, 1996 May 23, V251 N2:252-258.

  • Wettern, M. und von Kampen, J. (1996)
    Das Ubiquitin-System der Zellen.
    Spektrum Wissenschaft, Januar-Heft, 70-78.

  • von Kampen, J., Wettern, M. und Schulz, M. (1996)
    The ubiquitin system in plants.
    Physiol. Plantarum 97, 618-624.



  • Köhler U; Liaud MF; Mendel RR; Cerff R; and others.
    The maize Gapc4 promoter confers anaerobic reporter gene expression and shows homology to the maize anthocyanin regulatory locus C1.
    Plant Molecular Biology, 1995 Dec, V29 N6:1293-1298.

  • Schulze J; Balko C; Zellner B; Koprek T; and others.
    Biolistic transformation of cucumber using embryogenic suspension cultures - long-term expression of reporter genes.
    Plant Science, 1995 Dec 29, V112 N2:197-206.

  • Stallmeyer B; Nerlich A; Schiemann J; Brinkmann H; and others.
    Molybdenum cofactor biosynthesis - the Arabidopsis thaliana cDna cnx1 encodes a multifunctional two-domain protein homologous to a mammalian neuroprotein, the insect protein cinnamon and three Escherichia coli proteins.
    Plant Journal, 1995 Nov, V8 N5:751-762.

  • Mendel, R.R., and Stallmeyer, B.:
    Molybdenum cofactor (nitrate reductase) biosynthesis in plants: First molecular analysis.
    In: Current Issues in Plant Molecular and Cellular Biology (Eds: M. Terzi, R. Cella, A. Falavigna). Kluwer Academic Publishers, Dordrecht, Boston, London 1995, p. 577 - 582.

  • Hänsch R; Koprek T; Mendel RR; Schulze J.
    An improved protocol for eliminating endogenous beta-glucuronidase background in barley.
    Plant Science, 1995 Jan, V105 N1:63-69.

  • von Kampen, J., Nieländer, U. und Wettern, M. (1995)
    Transcription of ubiquitin genes in Chlamydomonas reinhardtii: involvement in stress response and cell cycle.
    Planta 197, 528-534.

  • Henze, K., Badr, A., Wettern, M., Cerff, R. und Martin, W. (1995)
    A nuclear gene of eubacterial origin in Euglena gracilis reflects cryptic endosymbioses during protist evolution.
    Pro. Natl. Acad. Sci. USA 92, 9122-9126.

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